What proportion of the population of Spain has developed antibodies to the SARS-CoV-2 infection?

Bottom Line: Only approximately 5% of the Spanish population has developed antibodies to SARS-CoV-2 after the initial epidemic wave. Reference: Pollán, M. et al. Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study. The Lancet (2020). https://doi.org/10.1016/s0140-6736(20)31483-5 Date Published: 6 July 2020 Synopsis: Spain was one of the European countries most affected by the […]

Can public health campaigns help change behaviours that lead to reduced COVID-19 transmission?

Bottom Line: A public health campaign in the Netherlands using a widely-circulated news article with infographics and a video featuring a social media influencer led to increases in hand washing, greater awareness of face touching, and physical distancing. Reference: Yousuf, H. et al. Association of a public health campaign about coronavirus disease 2019 promoted by news […]

How is the SARS-CoV-2 virus able to invade the brain and cause an infection?

Bottom Line: The slightly positively charged spike protein is thought to allow the virus to enter the central nervous system and cause a brain infection. Reference: Hassanzadeh, K. et al. Considerations around the SARS-Cov-2 spike protein with particular attention to COVID-19 brain infection and neurological symptoms. ACS Chemical Neuroscience (2020). https://doi.org/10.1021/acschemneuro.0c00373 Date Published: 6 July 2020 Synopsis: Increasing […]

Has the COVID-19 pandemic caused changes in mental health symptoms of individuals?

Bottom Line: This study sampled over 55,000 individuals and found an overall increase in mental health symptoms of depression, anxiety, insomnia, and acute stress in people either directly or indirectly affected by COVID-19. Reference: Shi, L. et al. Prevalence of and Risk Factors Associated With Mental Health Symptoms Among the General Population in China During the […]

Does exposure to COVID-19 protect against reinfection early on in recovery?

Bottom Line: Infection with SARS-CoV-2 was shown to protect against reinfection during the early recovery phase in rhesus monkeys. Reference: Deng, W. et al. Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques. Science (2020). DOI: 10.1126/science.abc5343 Date Published: 2 July 2020 Synopsis: There have been reports of patients who recover from COVID-19 illness and have undetectable […]

During the COVID-19 pandemic, have there been more deaths of any cause than would have been expected based on the death rate in previous years?

Bottom Line: From March 1 through to May 30, 2020 there were 120,000 more deaths than would have been expected based on previous years, with roughly 80% of these extra deaths being due to COVID-19 and 20% being due to causes other than COVID-19. Reference: Weinberger, D.M. et al. Estimation of excess deaths associated with the […]

What clinical characteristics of patients with cancer are associated with worse COVID-19 disease?

Bottom Line: Older age and medications called immune checkpoint inhibitors are associated with more severe COVID-19 infections in patients with cancer. Reference: Robilotti, E.V. et al. Determinants of COVID-19 disease severity in patients with cancer. Nat Med (2020). https://doi.org/10.1038/s41591-020-0979-0 Date Published: 24 June 2020 Synopsis: Previous studies have shown that patients with cancer have a higher risk of death […]

How did adolescents view COVID-19 at the start of the pandemic, and how did their attitudes shape their associated behaviors?

Bottom Line: The majority of adolescents did not practice physical distancing, but did practice disinfecting behaviors and followed COVID-related news. Those who viewed the virus as more severe were significantly more likely to follow the news, practice physical distancing, and disinfecting behaviors. Reference: Oosterhoff, B. & Palmer, C.A. Attitudes and psychological factors associated with news monitoring, social […]

What are the neurological and neuropsychiatric complications associated with COVID-19 infection?

Bottom Line: Cerebrovascular events, altered mental status, and peripheral neurologic syndromes have been noted in some patients affected by COVID-19. Although this link has been seen, more research is needed to understand why these syndromes occur, and potential risk factors leading to them. Reference: Varatharaj, A. et al. Neurological and neuropsychiatric complications of COVID-19 in 153 […]

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