Is there an association between COVID-19 and Kawasaki disease in the pediatric population?

Bottom Line:

The authors describe a case of a 6-month old infant without respiratory symptoms who was diagnosed with both COVID-19 and Kawasaki disease, suggesting possible association between the two diseases.

Reference:

Jones, V.G. et al. COVID-19 and Kawasaki Disease: Novel Virus and Novel Case. Hospital Pediatrics (2020). DOI: 10.1542/hpeds.2020-0123. Available from: https://hosppeds.aappublications.org/content/early/2020/04/06/hpeds.2020-0123

Date Published:

7 April 2020

Synopsis:

Kawasaki disease (KD) is a vasculitis affecting children that can cause heart disease. Here, the authors document the first report of concurrent KD and COVID-19 infection in a 6-month old infant. Initially, she presented to pediatric urgent care with fever, fussiness and refusal to eat. Two day into the fever, she developed an erythematous (red), seemingly non-pruritic (not itchy), blotchy rash. After admission to the pediatric floor on Day 5, she met classic diagnostic criteria for KD, and was subsequently diagnosed with COVID-19 by RT-PCR testing. The authors speculate that there may be a possible association between KD and COVID-19, especially since as high as 42% of patients with KD test positive for a respiratory viral infection in the 30-days leading up to diagnosis of KD.

Summary by: Mike Ge