What are current pharmacological treatments for COVID-19?

Bottom Line:

There are currently no proven effective therapies for COVID-19, but several promising candidates are being tested, such as remdesivir.

Reference:

Sanders, J.M. et al. Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19). JAMA (2020). doi: 10.1001/jama.2020.6019

Date Published:

April 13, 2020

Synopsis:

The authors reviewed the present literature to provide an update on current pharmaceutical treatments targeting SARS-CoV-2. Among repurposed drugs, they found that chloroquine and hydroxychloroquine demonstrated in vitro viral inhibitory activity and were used to successfully treat 100 COVID-19 cases in China. There remains inconclusive evidence on the Lopinavir/Ritonavir antivirals with limited case reports and cohort studies testing it. Remdesivir is a promising potential drug for COVID-19 due to its broad-spectrum, potent in vitro activity against several coronaviruses. Further randomized control trials into these novel or repurposed drugs will go a long way towards guiding treatment efforts for COVID-19.

Summary by: Mike Ge