What precautions need to be taken for patients with COVID-19 undergoing gynecologic surgery?

Bottom Line: All patients undergoing gynecologic surgery during the pandemic need to have a health risk assessment performed before any type of surgery and patients with confirmed or suspected infections should postpone their surgeries until they have fully recovered from the active infection. Reference: Chiofalo, B. et al. Practical Recommendations for Gynecologic Surgery During the [...]

Can a machine learning program use chest CT with clinical symptoms to augment early detection of SARS-CoV-2 infection?

Bottom Line: Artificial intelligence can help diagnose COVID-19 in patients with equal sensitivity to a senior radiologist, allowing rapid diagnosis particularly when there is a shortage of RT–PCR test kits. Reference: Mei, X. et al. Artificial intelligence–enabled rapid diagnosis of patients with COVID-19. Nature Medicine (2020). https://doi.org/10.1038/s41591-020-0931-3 Date Published: 19 May 2020 Synopsis: Current diagnosis [...]

Are there racial and ethnic differences in COVID-19 outcomes?

Bottom Line: Differences in in-hospital mortality to COVID-19 between white and black patients reflect racial differences in the types of jobs with increased risk of community exposure, socioeconomic status, prevalence of chronic conditions, and characteristics of initial clinical presentation . Reference: Price-Haywood, E.G. et al. Hospitalization and Mortality among Black Patients and White Patients with [...]

What are the interactions between COVID-19 therapies and anti-cancer drugs?

Bottom Line: Currently, the scientific literature does not have enough evidence to suggest specific side-effects to using anti-cancer drugs in combination with COVID-19 therapies. There are some drugs that should be avoided to avoid side effects and interactions with COVID-19 drugs but more research needs to be done to determine how these cancer drugs interact [...]

Does lying face down help COVID-19 patients breathe?

Bottom Line: Initial evidence suggests potential improvement in oxygenation and reduced lung injury from patients adopting the prone position (lying face down and back up) in spontaneous and assisted breathing. Reference: Telias, I. et al. Is the Prone Position Helpful During Spontaneous Breathing in Patients With COVID-19? JAMA (2020). DOI:10.1001/jama.2020.8539 Date Published: 15 May 2020 [...]

Are COVID-19 infection rates and severity different between patients who have received BCG vaccinations compared to those who have not?

Bottom Line: There was no statistically significant difference in the proportion of patients with COVID-19 positive test results in the BCG-vaccinated group compared to the unvaccinated group Reference: Hamiel, U. et al. SARS-CoV-2 rates in BCG-vaccinated and unvaccinated young adults. JAMA (2020).  DOI:10.1001/jama.2020.8189 Date Published: 13 May 2020 Synopsis: A potential reason for varied infection [...]

What are the clinical features of COVID-19 in patients with spinal cord injury?

Bottom Line: Patients with spinal cord injury and a COVID-19 infection show fewer symptoms than the general population but present with similar or worse severity. Reference: Rodriguez-Cola, M. et al. Clinical features of coronavirus disease 2019 (COVID-19) in a cohort of patients with disability due to spinal cord injury. Spinal Cord Series and Cases (2020). [...]

Is hydroxychloroquine treatment associated with improved COVID-19 outcomes?

Bottom Line: In 1,446 patients hospitalized with COVID-19, hydroxychloroquine administration was not associated with significantly higher or lower risk of death. Reference: Geleris, J. et al. Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19. New England Journal of Medicine (2020). DOI: 10.1056/NEJMoa2012410 Date Published: 7 May 2020 Synopsis: The researchers performed an observational study [...]

What is the relationship between COVID-19 and diabetes mellitus?

Bottom Line: Diabetes mellitus (DM) can lead to poor outcomes in patients with COVID-19 due to a compromised immune system, inflammation, and use of certain medications (e.g. RAAS antagonists). Conversely, in patients who have diabetes mellitus, a COVID-19 infection can worsen glucose control because of the drugs used to treat the infection (e.g. corticosteroids, lopinavir/ritonavir), [...]