Clinical Findings and Disease Severity in Hospitalized Pregnant Women With Coronavirus Disease 2019 (COVID-19)

Bottom Line: While 20% of women from this study had severe disease (e.g. declining respiratory function, admission to ICU, or both), there were no deaths observed in these patients. In additions, factors such as Body Mass Index (BMI), respiratory rate, and heart rate were associated with severe disease. Reference: Valeria, SM. et al. Clinical Findings and [...]

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

Bottom Line: Among hospitalized COVID-19 patients, administering dexamethasone resulted in lower 28-day mortality in patients receiving invasive mechanical ventilation or oxygen alone. Reference: Horby, P. et al. Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report. NEJM (2020).  https://www.nejm.org/doi/10.1056/NEJMoa2021436 Date Published: 17 July 2020 Synopsis: Preliminary results from the REOVERY trial indicate that the use of dexamethasone [...]

Clinical update on COVID-19 in pregnancy: A review article

Bottom Line: Current evidence does not suggest increased risk of severe COVID-19 infection in pregnant women, although high-risk obstetrical patients should be appropriately evaluated and managed. Reference: Gillian, RA. et al. Clinical update on COVID‐19 in pregnancy: A review article. The Journal of  Obstetrics and Gynaecology Research .2020). https://doi.org/10.1111/jog.14321 Date Published: 4 June 2020 Synopsis: In general, pregnant [...]

Cognitive Bias and Public Health Policy During the COVID-19 Pandemic

Bottom Line: Cognitive errors may distract policy makers and citizens from making appropriate public health decisions that reduce the impact of COVID-19 across the entire population. Reference: Halpern, SD. et al. Cognitive Bias and Public Health Policy During the COVID-19 Pandemic. JAMA (2020). doi:10.1001/jama.2020.11623 Date Published: 29 June 2020 Synopsis: Despite an emphasis on using evidence to guide [...]

Vertical transmission risk of SARS-CoV-2 infection in the third trimester: a systematic scoping review

Bottom Line: Currently, there is no evidence to suggest that COVID-19 can be passed from mom to baby during the third trimester. More studies are needed to understand how to manage babies born to mothers with a COVID-19 infection. Reference: Thomas, P. et al. Vertical transmission risk of SARS-CoV-2 infection in the third trimester: a systematic [...]

Renin-Angiotensin-Aldosterone Inhibitors and Susceptibility to and Severity of COVID-19

Bottom Line: Contrary to initial beliefs, use of ACEIs and ARBs is not associated with increased susceptibility to SARS-CoV-2 infection or increased severity of COVID-19. Reference: Curfman, G. Renin-Angiotensin-Aldosterone Inhibitors and Susceptibility to and Severity of COVID-19. JAMA (2020). DOI:10.1001/jama.2020.11401 Date Published: 19 June 2020 Synopsis: To enter a human cell, SARS-CoV-2 uses its spike protein and two [...]

Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility

Bottom Line: Positive SARS-CoV-2 (the virus causing COVID-19) screens were observed in more than half of residents who did not have symptoms at the time of testing. Infection-control strategies for residents with symptoms were not sufficient to prevent viral transmission. Reference: Arons, M.M. et al. Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility. The New [...]

Early evidence of pronounced brain involvement in fatal COVID-19 outcomes

Bottom Line: Through possible mechanisms of viral infiltration, immune response, and hypercoagulability, COVID-19 appears to cause encephalitis and meningitis in a small sample of autopsied patients. Reference: Hann von Weyhern, C. et al. Early evidence of pronounced brain involvement in fatal COVID-19 outcomes. The Lancet (2020). https://doi.org/10.1016/S0140-6736(20)31282-4. Date Published: 4 June 2020 Synopsis: The researchers studied six autopsied patients [...]

Creating dermatology guidelines for COVID-19: The pitfalls of applying evidence-based medicine to an emerging infectious disease

Bottom Line: Although the guidelines for an emerging infectious disease are more reliant on expert advice as opposed to evidence-based medicine, efforts must be made to create amendable guidelines based on the best available information at a time. Reference: Freeman, E.E. et al. Creating dermatology guidelines for COVID-19: The pitfalls of applying evidence-based medicine to [...]

Practical Recommendations for Gynecologic Surgery during the COVID-19 Pandemic

Bottom Line: All patients undergoing gynecologic surgery during the pandemic need to have a health risk assessment performed before any type of surgery. Patients with confirmed or suspected infections need to postpone their surgeries until they have fully recovered from the active infection. Reference: Chiofalo, B. et al. Practical recommendations for gynecologic surgery during the COVID-19 [...]